Este fenómeno es conocido como efecto Jod-Basedow. El tratamiento con propiltiouracilo en dosis decrecientes consiguió un estado eutiroideo y mejoró la . Efectos de las hormomas tiroideas en el corazón. Visits . por el efecto de Wolff- Chaikoff, además de hipertiroidismo (mediado por el efecto de Jod-Basedow. de hipertiroidismo (mediado por el efecto de Jod-Basedow. En ambos casos, la causa subyacente es por la alta concentración de yodo en este medicamento.

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Jod-Basedow phenomenon

Thyroid hormones have a significant impact on heart function, mediated by genomic and non-genomic effects. Consequently, thyroid hormone deficiencies, as well as excesses, are expected to result in profound changes in cardiac function regulation and cardiovascular hemodynamics.


Thyroid hormones upregulate the expression efectto the sarcoplasmic reticulum calcium-activated ATPase and downregulate the expression of phospholamban. Overall, hyperthyroidism is characterized by an increase in resting heart rate, blood volume, stroke volume, myocardial contractility, and ejection fraction.

On the other hand, in a hypothyroid state, thyroid hormone deficiency results in joe heart rate and weakening of myocardial contraction and relaxation, with prolonged systolic and early diastolic times. Cardiac preload is decreased due to impaired diastolic function. Cardiac afterload is increased, and chronotropic and inotropic functions are reduced. Subclinical thyroid dysfunction is relatively common in patients over 65 years of age.

In general, subclinical hypothyroidism increases the risk of coronary heart disease CHD mortality and CHD events, but not of total mortality. The risk of CHD mortality and atrial fibrillation but not other outcomes in subclinical bassedow is higher among patients with very low levels of thyrotropin. Finally, medications such as amiodarone may induce hypothyroidism mediated by the Wolff—Chaikoffas well as hyperthyroidism mediated by the Jod—Basedow effect.

In both instances, the underlying cause is the high concentration of iodine in this medication. Previous article Next article.

November – December Pages Hernando Vargas-Uricoechea a.


This item has received. Show more Show less. Cardiac and hemodynamic consequences of hyperthyroidism. Cardiovascular and hemodynamic changes in a efefto state. In both instances, the underlying cause is the high concentration of iodine in this medication.

Wolff–Chaikoff effect – Wikipedia

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